Archive for the 'Treatment' Category



Bate et al. tested antimalarial quality for several drugs in 6 countries across sub-Saharan Africa and found an alarming 35% were substandard as gauged by thin layer chromatography or dissolution tests. The authors did not attempt to assess whether counterfeit or not as the outcome would remain the same - i.e. the drugs are substandard […]

The world’s most potent antimalarial, artemisinin, is not available to physicians in the United States but a CDC investigational new drug (IND) project is trying to change that. Over 1,000 cases of malaria are imported into the United States every year and many cases present with severe complications as most travelers lack any natural immunity. […]

GlaxoSmithKline pulled Lapdap (chloroproguanil-dapsone) from the market and ended the development of Dacart (Lapdap+artesunate) after phase III trials of the drugs showed significant hemoglobin reductions in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. Patient’s with G6PD deficiency have weaker red blood cell membranes which can rupture when exposed to oxidative stress caused by certain drugs […]